Infantile hemangiomas are the most common benign soft tissue tumors of infancy and childhood. Most cases are sporadic and are not inherited and they are most frequently seen in the head and neck region. They may be absent or small at birth, but typically enter a proliferative phase for 6-12 months in which the tumor grows to a raised bright red tumor with a smooth or irregular outer surface, but tend to regress in later childhood. Today the treatment of choice is systemic propranolol which is believed to work by blocking the pro-angiogenic signaling of VEGF and bFGF.