Squamous cell carcinoma (SCC) is a malignant tumor of the squamous layer of cells of the epidermis, showing keratinocyte differentiation. It is the second most common malignancy affecting the eyelid skin, accounting for 5-10% of such lesions. The majority of SCCs arise from preexisting lesions such as actinic keratosis, Bowen disease, radiation dermatoses, burn scars, and chronic inflammatory lesions. Clinically, SCC appears as a slowly enlarging, flesh-colored or erythematous, nodule or hyperkeratotic lesion with an indurated border and a central ulcer bed often covered with a thick crust or scale, which may bleed easily. Neglected lesions may become more infiltrated and ulcerated with a heaped-up rim.